- Product Details
Keywords
- 120511-73-1 Anastrozole
- 120511-73-1 Anastrozole 98%
- 120511-73-1 White crystalline powder
Quick Details
- ProName: Oral Steroids Anastrozole/Arimidex/Tab...
- CasNo: 120511-73-1
- Molecular Formula: C17H19N5
- Appearance: White crystalline powder
- Application: Pharmaceutical intermediates
- DeliveryTime: Within 5-7 work days after confirming ...
- PackAge: according to customer's requirement
- Port: Shanghai
- ProductionCapacity: 500 Kilogram/Month
- Purity: 98%
- Storage: cool and dry
- Transportation: EMS, DHL, FedEx,TNT
- LimitNum: 10 Gram
Superiority
Run-Biotech provides a broad and integrated portfolio of services throughout the drug R&D process. Our services are designed to help our worldwide customers shorten the discovery and development time and lower the cost of drug and medical device R&D through cost-effective and efficient outsourcing solutions.
Based on our technical expertise and excellent research facilities, we successfully establish facilities, advanced R & D services technology platform. We will achieve leapfrog all-round development in the field of chemical synthesis, medicinal chemistry, biological and so on.
Run-Biotech has further enhanced the integrated services with analytical services, bio-analytical services, process research, process development services, API manufacturing services, discovery biology, pharmacology, formulation services, biologics manufacturing services, antibody, biological research reagent manufacturing and sales services.
Run-Biotech has its own logistics center, provides the professional, personalized one-stop services, offers a variety of technologies and products and services for the world's major technology and industrial customers.
Run-Biotech has a professional team with rich creative talents, every day there will be new technologies and new products.Run-Biotech is committed to the production and sales of high-purity organic, analytical reagents, standard substances, organometallic catalysts, pharmaceutical intermediates, as well as ultra fine materials. We are able to provide small quantities, varieties of raw materials at very high speed , meeting the needs of experimental, pilot scale as well as large-scale production.
Details
Detail
Product name: Anastrozole
Alias :Arimidex ,Tetramethyl-5-(1H-1,2,4-triazol-1ylmethyl)1,3-benzenediacetionitrile
CAS : 120511-73-1
Assay : 98%~102%
Appearance : White crystalline powder
Active life cycle : 6 hours
MF : C17H19N5
MW : 293.37
Grade : Pharmaceutical Grade
Storage: Shading, confined preservation
Delivery time :within 24 hours upon receipt of payment
Delivery: EMS, DHL, TNT, FedEx, UPS
Usage : Anastrozole is a potent non-steroidal aromatase inhibitors , which lead the decrease of plasma level of estrogen, inhibited the growth of breast cancer. For the treatment of advanced breast cancer in postmenopausal women patients.
Description
Anastrozole is a drug indicated in the treatment of breast cancer in post-menopausal women. It is used both in adjuvant therapy (i.e. following surgery) and in metastatic breast cancer.
Many breast cancers also contain aromatase; the importance of tumor-generated estrogens is uncertain. Treatment of breast cancer has included efforts to decrease estrogen levels by ovariectomy premenopausally and by use of anti-estrogens and progestational agents both pre- and post-menopausally, and these interventions lead to decreased tumor mass or delayed progression of tumor growth in some women. Anastrozole is a potent and selective non-steroidal aromatase inhibitor. It significantly lowers serum estradiol concentrations and has no detectable effect on formation of adrenal corticosteroids or aldosterone.
Application
Three azole aromatase inhibitors are potent selective, it can inhibit the cytochrome P-450 dependent aromatase thereby blocking the biosynthesis of estrogen, but estrogen is the main factor that stimulates the growth of breast cancer cells.
The treatment of breast cancer, especially for those with adjuvant hormone therapy after menopause after recurrence of women with advanced breast cancer.
Although Arimidex does increase testosterone levels slightly in the body, it is more often used in conjunction with other steroids to lower estrogen in the body. Many anabolic steroids will convert, or aromatize, in the body into estrogen, which causes many of the unwanted side effects like bloating and acne. Arimidex is one of the best compounds to lower the aromatizing effect of steroids.
As to female. Many breast cancers are stimulated to grow by the female sex hormones oestrogen and progesterone. These breast cancers can be treated with drugs that block the effects of these hormones. Arimidex blocks the process of aromatisation. So it lowers the amount of oestrogen in the body. In advanced breast cancer the cancer cells may grow more slowly or stop growing completely.
As to male. Anastrozole may also be a part of treatment for men suffering from prostate cancer. In rare cases when a male patient has breast cancer, anastrozole may also be a treatment option. It is also a good choice for the treatment of men hair loss.
As to bodybuilders. Another use of Anastrozole for men is to maintain a powerfully-built and bulky physique among bodybuilders, especially those who take anabolic steroids. One function of steroids is that it mimics the actions of naturally occurring testosterone, resulting in the increase of protein levels, muscle buildup, and strength improvement.
Specification
Items | Standard | Results |
Description | White crystalline powder | Complies |
Solubility | Freely soluble in methanol,acetone,ethanol and tetrahydrofuran.And very soluble in acetonitrile | Complies |
Total Impurity | max.0.5% | 0.18% |
Total Unspecified Impurity | max. 0.2% | 0.08% |
Individual unspecified impurlty | max. 0.1% | 0.05% |
Related compound B | max. 0.2% | 0.07% |
Related compound C | max. 0.2% | 0.04% |
Related compound D | max. 0.1% | 0.05% |
Related compound E | max. 0.1% | 0.06% |
Limit of cyclohexane | max. 0.08% | ND |
Limit of ethylacetate | max. 0.1% | 0.07% |
Melting point | 81.0~84.0℃ | 82.5~83.2℃ |
Water | max. 0.3% | 0.21% |
Residue on ignition | max. 0.1% | 0.07% |
Heavy Metals | max.0.001% | Complies |
Assay(HPLC) | 98.0%~102.0% | 99.8% |
Storage | Cool and dry | |
Conclusion | It complies to USP32 . |